abstract：:Deep brain stimulation (DBS) is used as an alternative therapeutic procedure for pharmacoresistant psychiatric disorders. Recently the thalamic reticular nucleus (TRN) gained attention due to the description of a novel pathway from the amygdala to this nucleus suggesting that may be differentially disrupted in mood di...

journal_title：Behavioural brain research

authors： Magdaleno-Madrigal VM,Pantoja-Jiménez CR,Bazaldúa A,Fernández-Mas R,Almazán-Alvarado S,Bolaños-Alejos F,Ortíz-López L,Ramírez-Rodriguez GB

更新日期：2016-11-01 00:00:00

abstract：:Exposure to early stressful adverse life events such as maternal separation severely impacts the development of the nervous system. Using immunohistochemistry, quantitative PCR and Western blot approaches, we found that alpha6 subunit-containing GABAA receptors (Gabra6-containing GABAA Rs) were expressed on hippocampa...

journal_title：Behavioural brain research

authors： Yang L,Xu T,Zhang K,Wei Z,Li X,Huang M,Rose GM,Cai X

更新日期：2016-10-15 00:00:00

abstract：:Chemical signals play a critical role in interindividual communication, including mother-young relationships. Detecting odor cues released by the mammary area is vital to the newborn's survival. European rabbit females secret a mammary pheromone (MP) in their milk, which releases sucking-related orocephalic movements ...

journal_title：Behavioural brain research

authors： Schneider NY,Piccin C,Datiche F,Coureaud G

更新日期：2016-10-15 00:00:00

abstract：:The role of dopamine (DA) receptors in spatial memory consolidation has been demonstrated in numerous brain regions, among others in the nucleus accumbens which innervates the ventral pallidum (VP). The VP contains both D1 and D2 DA receptors. We have recently shown that the VP D1 DA receptor activation facilitates co...

journal_title：Behavioural brain research

authors： Péczely L,Ollmann T,László K,Kovács A,Gálosi R,Kertes E,Zagorácz O,Kállai V,Karádi Z,Lénárd L

更新日期：2016-10-15 00:00:00

abstract：:The Wistar-Kyoto (WKY) rat has been proposed as a model of anxiety vulnerability as it exhibits pronounced behavioral inhibition, passive avoidance, exaggerated startle response, enhanced HPA-axis activation, and active avoidance that is resistant to extinction. Accumulating evidence suggests that WKY rats respond dif...

journal_title：Behavioural brain research

authors： Dennis TS,Beck KD,Cominski TP,Bobzean SAM,Kuzhikandathil EV,Servatius RJ,Perrotti LI

更新日期：2016-10-15 00:00:00

abstract：:Rats with lesions in the perirhinal cortex and their control group learnt to discriminate between mirror-imaged visual landmarks to find a submerged platform in a watermaze. Rats initially learnt this discrimination passively, in that they were repeatedly placed on the platform in one corner of a square watermaze with...

journal_title：Behavioural brain research

authors： Nelson AJD,Olarte-Sánchez CM,Amin E,Aggleton JP

更新日期：2016-10-15 00:00:00

abstract：:Simultaneous presentation of alternating innocuous warm and cold stimuli induces in most humans a painful sensation called thermal grill illusion (TGI). Here, pain is elicited although nociceptors are not activated. Upon back-translation of behavioural correlates from humans to animals, we found that neither cats nor ...

journal_title：Behavioural brain research

authors： Boettger MK,Ditze G,Bär KJ,Krüdewagen EM,Schaible HG

更新日期：2016-10-15 00:00:00

abstract：:The hippocampus plays a vital role in processing contextual memories and reward related learning tasks, such as conditioned place preference (CPP). Among the neurotransmitters in the hippocampus, dopamine is deeply involved in reward-related processes. This study assessed the role of D1- and D2-like dopamine receptors...

journal_title：Behavioural brain research

authors： Assar N,Mahmoudi D,Farhoudian A,Farhadi MH,Fatahi Z,Haghparast A

更新日期：2016-10-01 00:00:00

abstract：:The ameliorating effects of the ethyl acetate fraction from Dendropanax morbifera (EFDM) on cognitive impairment in high-fat diet (HFD)-induced diabetic mice were examined by measuring its possible pharmacological activities. Administration of EFDM (20 and 50mg/kg body weight) in HFD-induced diabetic mice significantl...

journal_title：Behavioural brain research

authors： Kim JM,Park SK,Guo TJ,Kang JY,Ha JS,Lee du S,Lee U,Heo HJ

更新日期：2016-10-01 00:00:00

abstract：:Xenin is a gut hormone that reduces food intake by partly acting through the hypothalamus via neurotensin receptor 1 (Ntsr1). However, specific signaling pathways that mediate xenin-induced feeding suppression are not fully understood. Activation of Ntsr1 leads to the activation of the extracellular signal-regulated k...

journal_title：Behavioural brain research

authors： Kim ER,Lew PS,Spirkina A,Mizuno TM

更新日期：2016-10-01 00:00:00

abstract：:Individuals with trait anxiety are often considered to be predisposed to psychiatric disorders. However, there is great heterogeneity in the development of psychiatric disorders in this group of people and the nature of the trait anxiety is still unclear. So, we decided to explore the correlations of brain structure a...

journal_title：Behavioural brain research

authors： Yin P,Zhang M,Hou X,Tan Y,Fu Y,Qiu J

更新日期：2016-10-01 00:00:00

abstract：:Self-injurious behaviour (SIB) is a debilitating characteristic that is highly prevalent in autism and other neurodevelopmental disorders. Pathological anxiety is also common, and there are reports of comorbid anxiety and self-injury in some children. We have investigated potential interactions between anxiety and sel...

journal_title：Behavioural brain research

authors： Yuan X,Devine DP

更新日期：2016-09-15 00:00:00

abstract：:Enhanced anxiety is a salient feature of a number of psychiatric disorders including anxiety disorders, trauma-related disorders and depression. Although aberrant expression of various genes has been detected in patients suffering from persistent high anxiety as well as in high anxiety rodent models, the molecular mec...

journal_title：Behavioural brain research

authors： Wille A,Amort T,Singewald N,Sartori SB,Lusser A

更新日期：2016-09-15 00:00:00

abstract：:Value-based action selection has been suggested to be realized in the corticostriatal local circuits through competition among neural populations. In this article, we review theoretical and experimental studies that have constructed and verified this notion, and provide new perspectives on how the local-circuit select...

journal_title：Behavioural brain research

authors： Morita K,Jitsev J,Morrison A

更新日期：2016-09-15 00:00:00

abstract：:Among learning and memory processes, fear memories are crucial in some psychiatric disorders like post-traumatic stress disorder (PTSD). Accumulating evidence shows that the sigma-1 receptor (Sig-1R) has comprehensive involvement in cognitive impairment and neuroprotective effects. It has also been reported that BDNF ...

journal_title：Behavioural brain research

authors： Ji LL,Peng JB,Fu CH,Cao D,Li D,Tong L,Wang ZY

更新日期：2016-09-15 00:00:00

abstract：:Increasing evidence suggests that disruptions of synaptic functions correlate with the severity of cognitive deficit in Alzheimer's disease (AD). Our previous study demonstrated that baicalein enhances long-term potentiation (LTP) in acute rat hippocampal slices and improves hippocampus-dependent contextual fear condi...

journal_title：Behavioural brain research

authors： Gu XH,Xu LJ,Liu ZQ,Wei B,Yang YJ,Xu GG,Yin XP,Wang W

更新日期：2016-09-15 00:00:00

abstract：:Clinical research has identified developmental delay and physical malformations in children prenatally exposed to the antiepileptic drug (AED) valproic acid (VPA). However, the early signs of neurodevelopmental deficits, their evolution during postnatal development and growth, and the dose effects of VPA are not well ...

journal_title：Behavioural brain research

authors： Podgorac J,Pešić V,Pavković Ž,Martać L,Kanazir S,Filipović L,Sekulić S

更新日期：2016-09-15 00:00:00

abstract：:Although drug rewards and natural rewards share neural substrates, the neuronal activation patterns and mechanisms behind the interaction between cocaine and social reward are poorly understood. Here, we investigated the conditioned place preference (CPP) in social (conspecific) vs cocaine conditioning, and the expres...

journal_title：Behavioural brain research

authors： Liu C,Wang J,Zhan B,Cheng G

更新日期：2016-09-01 00:00:00

abstract：:Cannabidiol (CBD) is a major non-psychoactive compound from Cannabis sativa plant. Given that CBD reduces psychotic symptoms without inducing extrapyramidal motor side-effects in animal models and schizophrenia patients, it has been proposed to act as an atypical antipsychotic. In addition, CBD reduced catalepsy induc...

journal_title：Behavioural brain research

authors： Sonego AB,Gomes FV,Del Bel EA,Guimaraes FS

更新日期：2016-08-01 00:00:00

abstract：:The current study examined sex differences in initial and subsequent strategies in solving a navigational problem within a virtual reality environment. We tested 163 undergraduates on a virtual T-maze task that included probe trials designed to assess whether participants were responding using either a place or respon...

journal_title：Behavioural brain research

authors： Astur RS,Purton AJ,Zaniewski MJ,Cimadevilla J,Markus EJ

更新日期：2016-07-15 00:00:00

abstract：:Corticostriatal circuitry supports flexible reward learning and emotional behavior from the critical neurodevelopmental stage of adolescence through adulthood. It is still poorly understood how prescription drug exposure in adolescence may impact these outcomes in the long-term. We studied adolescent methylphenidate (...

journal_title：Behavioural brain research

authors： Izquierdo A,Pozos H,Torre Ade L,DeShields S,Cevallos J,Rodriguez J,Stolyarova A

更新日期：2016-07-15 00:00:00

abstract：:Major depressive disorder (MDD) is a debilitating illness. However, the underlying molecular mechanisms of depression remain largely unknown. Increasing evidence supports that inflammatory cytokine disturbances may be associated with the pathophysiology of depression in humans. Systemic administration of lipopolysacch...

journal_title：Behavioural brain research

authors： Wu Y,Fu Y,Rao C,Li W,Liang Z,Zhou C,Shen P,Cheng P,Zeng L,Zhu D,Zhao L,Xie P

更新日期：2016-07-15 00:00:00

abstract：:Early life stress in rodents is associated with increased amygdala volume in adulthood. In humans, the amygdala develops rapidly during the first two years of life. Thus, disturbed care during this period may be particularly important to amygdala development. In the context of a 30-year longitudinal study of impoveris...

journal_title：Behavioural brain research

authors： Lyons-Ruth K,Pechtel P,Yoon SA,Anderson CM,Teicher MH

更新日期：2016-07-15 00:00:00

abstract：:Chronic cerebral hypoperfusion (CCH) causes memory deficits and increases the risk of vascular dementia (VD) through several biologically plausible pathways. However, whether CCH causes prefrontal cortex (PFC)-dependent spatial working memory impairments and Baclofen, a GABAB receptor agonist, could ameliorate the imp...

journal_title：Behavioural brain research

authors： Luo P,Chen C,Lu Y,Fu T,Lu Q,Xu X,Li C,He Z,Guo L

更新日期：2016-07-15 00:00:00

abstract：:Binge eating is a dysregulated form of feeding behavior that occurs in multiple eating disorders including binge-eating disorder, the most common eating disorder. Feeding is a complex behavioral program supported through the function of multiple brain regions and influenced by a diverse array of receptor signaling pat...

journal_title：Behavioural brain research

authors： Hardaway JA,Jensen J,Kim M,Mazzone CM,Sugam JA,Diberto JF,Lowery-Gionta EG,Hwa LS,Pleil KE,Bulik CM,Kash TL

更新日期：2016-07-01 00:00:00

abstract：:Memory deficits may develop from a variety of neuropathologies including Alzheimer's disease dementia. During neurodegenerative conditions there are contributory factors such as neuroinflammation and amyloidogenesis involved in memory impairment. In the present study, dual properties of S100A9 protein as a pro-inflamm...

journal_title：Behavioural brain research

authors： Gruden MA,Davydova TV,Wang C,Narkevich VB,Fomina VG,Kudrin VS,Morozova-Roche LA,Sewell RD

更新日期：2016-06-01 00:00:00

abstract：:Recent work has found that behaviorally inhibited (BI) individuals exhibit enhanced eyeblink conditioning in omission and yoked training as well as with schedules of partial reinforcement. We hypothesized that spacing CS-US paired trials over a longer period of time by extending and varying the inter-trial interval (I...

journal_title：Behavioural brain research

authors： Allen MT,Myers CE,Servatius RJ

更新日期：2016-05-01 00:00:00

abstract：:Cancellation tasks are widely used for diagnosis of lateralized attentional deficits in stroke patients. A disorganized fashion of target cancellation has been hypothesized to reflect disturbed spatial exploration. In the current study we aimed to examine which lesion locations result in disorganized visual search dur...

journal_title：Behavioural brain research

authors： Ten Brink AF,Biesbroek JM,Kuijf HJ,Van der Stigchel S,Oort Q,Visser-Meily JM,Nijboer TC

更新日期：2016-05-01 00:00:00

abstract：:Development of the brain includes periods which can be critical for its normal maturation. The present study investigates specifically vulnerable peri-/postnatal periods in mice which are essential for understanding the etiology behind radiation induced neurotoxicity and functional defects, including evaluation of neu...

journal_title：Behavioural brain research

authors： Eriksson P,Buratovic S,Fredriksson A,Stenerlöw B,Sundell-Bergman S

更新日期：2016-05-01 00:00:00

abstract：:Prolonged and sustained stimulation of the hypothalamo-pituitary-adrenal axis have adverse effects on numerous brain regions, including the cerebellum. Motor coordination and motor learning are essential for animal and require the regulation of cerebellar neurons. The G-protein-coupled cannabinoid CB1 receptor coordin...

journal_title：Behavioural brain research

authors： Tomas-Roig J,Piscitelli F,Gil V,Del Río JA,Moore TP,Agbemenyah H,Salinas-Riester G,Pommerenke C,Lorenzen S,Beißbarth T,Hoyer-Fender S,Di Marzo V,Havemann-Reinecke U

更新日期：2016-04-15 00:00:00

abstract：:Caffeine is the psychostimulant most consumed worldwide. In moderate doses, it affords a beneficial effect in adults and upon aging, but has a deleterious effect during brain development. We now tested if caffeine consumption by rats (0.1, 0.3, 1.0 g/L in the drinking water, only during active cycle and weekdays) duri...

journal_title：Behavioural brain research

authors： Ardais AP,Rocha AS,Borges MF,Fioreze GT,Sallaberry C,Mioranzza S,Nunes F,Pagnussat N,Botton PH,Cunha RA,Porciúncula Lde O

更新日期：2016-04-15 00:00:00

abstract：:Stroke is a leading cause of long-term disability that most often results in impairment of a single limb, contralateral to the injury (paretic limb). While stroke survivors often receive some type of rehabilitative training, chronic deficits persist. It has been suggested that compensatory use of the nonparetic limb i...

journal_title：Behavioural brain research

authors： Kerr AL,Cheffer KA,Curtis MC,Rodriguez A

更新日期：2016-04-15 00:00:00

abstract：:Poor vascular health, atherosclerosis, or cardiac procedures in the elderly result in clinically silent microvascular infarcts that increase susceptibility to larger ischemic episodes and can precipitate changes in mood and cognition. Although the mechanisms that underlie ischemia-induced behavioral changes have not b...

journal_title：Behavioural brain research

authors： Nemeth CL,Miller AH,Tansey MG,Neigh GN

更新日期：2016-04-15 00:00:00

abstract：:Evidence from experimental animal studies convincingly argues for a role of pro-inflammatory cytokines due to surgical trauma in causing postoperative cognitive dysfunction. However, other studies have shown exposure to 2-4h of isoflurane anesthetic without surgical trauma can also impair cognitive function. We aimed ...

journal_title：Behavioural brain research

authors： Callaway JK,Wood C,Jenkins TA,Royse AG,Royse CF

更新日期：2016-04-15 00:00:00

abstract：:Heightened emotional states increase impulsive behaviors such as excessive ethanol consumption in humans. Though positive and negative affective states in rodents can be monitored in real-time through ultrasonic vocalization (USV) emissions, few animal studies have focused on the role of emotional status as a stimulus...

journal_title：Behavioural brain research

authors： Thakore N,Reno JM,Gonzales RA,Schallert T,Bell RL,Maddox WT,Duvauchelle CL

更新日期：2016-04-01 00:00:00

abstract：:Women are more susceptible than men to develop anxiety disorders, however, the mechanisms involved are still unclear. In this study, we investigated the role of group I metabotropic glutamate receptors (mGluRs), a target for anxiety disorders, and whether estradiol may modulate conflict-based anxiety in female rats by...

journal_title：Behavioural brain research

authors： De Jesús-Burgos MI,González-García S,Cruz-Santa Y,Pérez-Acevedo NL

更新日期：2016-04-01 00:00:00

abstract：:This study examined visual discrimination performance in a sample of older adults before, during and post treadmill walking at preferred walking speed and preferred walking speed +20%. Nine adults (6 females and 3 males) aged 60-77 years (mean age=67.1±5.7 years) undertook three trials each lasting 15 min, rest, walki...

journal_title：Behavioural brain research

authors： Duncan MJ,Smith M,Clarke ND,Eyre EL,Wright SL

更新日期：2016-04-01 00:00:00

abstract：:The present study was designed to explore the role of GSK-3β and NF-kB signaling in electric foot shock-induced stress and stress adaptation. Mice were subjected to foot shocks of 0.5mA intensity and 1s duration of 1h to produce acute stress. Animals were exposed to the same stressor for 5 days to induce stress adapta...

journal_title：Behavioural brain research

authors： Bali A,Jaggi AS

更新日期：2016-04-01 00:00:00

abstract：:We assessed early rearing conditions on aging-related changes in mouse behavior. Two isolated-housing groups, running wheel (IHRW) and empty cage (IHEC), were compared against two enriched environments, static (EEST) and dynamic (EEDY), both of which included toys and other mice. For EEDY, the location of toys and sou...

journal_title：Behavioural brain research

authors： Hong SL,Estrada-Sánchez AM,Barton SJ,Rebec GV

更新日期：2016-04-01 00:00:00

abstract：:Previous data have shown that the rat model of melatonin deficit can cause a number of neurobiological aberrations. The aim of the present study was to determine whether the antidepressant drug agomelatine, a MT1/MT2 melatoninergic receptor agonist/5-HT2C receptor antagonist is able to prevent some of the behavioral, ...

journal_title：Behavioural brain research

authors： Tchekalarova J,Nenchovska Z,Atanasova D,Atanasova M,Kortenska L,Stefanova M,Alova L,Lazarov N

更新日期：2016-04-01 00:00:00